Atypical lymphocytes what does it mean

Imaging is rarely required in the evaluation and management of lymphocytosis. Exceptions include patients whose lymphocytosis is thought to be most likely due to non-Hodgkin lymphoma, patients with palpable lymphadenopathy, patients with CLL and unfavorable cytogenetic abnormalities such as del 17p or del 11q who may have bulky intra-abdominal lymphadenopathy not appreciated on physical exam, and patients with a suspicion of T-ALL, to rule out the presence of a mediastinal mass.

It is unusual for immediate therapy to be required, and time should be taken to establish a definitive diagnosis prior to initiating treatment. One exception is in patients with aggressive lymphomas with circulating disease, such as Burkitt lymphoma, who may undergo spontaneous tumor lysis syndrome.

In patients with these metabolic derangements, aggressive electrolyte management, early administration of intravenous fluids, allopurinol, and, when required, rasburicase, are all important interventions to stabilize the patient while they are being worked up.

The prognosis of patients with lymphocytosis depends on the etiology of the condition, and discussions about prognosis with the patient and family should be postponed until a definitive diagnosis is established. If an identifiable cause of reactive lymphocytosis such as infectious mononucleosis is found, supportive care with observation is appropriate. However, should the lymphocytosis persist longterm for example, greater than 2 months , a re-evaluation must be performed, with a low threshold for pursuing studies to rule out an underlying malignant lymphocytosis.

If lymphocytosis is found to be intermittent, it should not be ignored, and further evaluation may be necessary. For example, patients with early stage CLL or indolent NHL may have borderline elevations of lymphocyte counts that wax and wane, and although these patients may not require immediate treatment, monitoring and definitive diagnostic evaluation should be performed.

The pathophysiology of lymphoctyosis varies widely, and depends on the underlying etiology driving the condition, as described in more detail in the topics covering these conditions. In both reactive and malignant lymphocytosis, the mechanisms leading to an increased number of circulating lymphocytes may include increased lymphocyte production, release of already formed lymphocytes into the blood, or decreased clearance of lymphocytes by the reticulo-endothelial system.

All rights reserved. No sponsor or advertiser has participated in, approved or paid for the content provided by Decision Support in Medicine LLC. Show More. Login Register. We want you to take advantage of everything Cancer Therapy Advisor has to offer. To view unlimited content, log in or register for free. Register now at no charge to access unlimited clinical news, full-length features, case studies, conference coverage, and more. Jump to Section What every physician needs to know about lymphocytosis: What features of the presentation will guide me toward possible causes and next treatment steps: What laboratory studies should you order to help make the diagnosis and how should you interpret the results?

What conditions can underlie lymphocytosis: When do you need to get more aggressive tests: What imaging studies if any will be helpful? What therapies should you initiate immediately and under what circumstances — even if root cause is unidentified? Test Findings. Atypical Lymphocytes. View Topic Outline.

Overview The term atypical lymphocyte is used to refer to any abnormal lymphocyte that does not appear reactive. Density routine urine test. Direct Bilirubin. Direct Coombs. E ECG. Egg White. Egg Yolk. Eggs and Parasites 1st, 2nd or 3rd specimen. Electroencephalogram EEG. Erythrocytes routine urine test. Factor VIII. Fat Bodies routine urine test. Fecal Calprotectin. Fecal Immunochemical Test. Femoral-Patellar Syndrome. Flu influenza. Folic acid and erythrocyte folates.

Free Kappa and Lambda. Free T3. Free T4. Free Testosterone. G G6PD Quantitative. Gamma globulins. Glucose routine urine test. Granular Casts. Grass Mix 1. Growth Hormone. Gynecological Cytology. H Hallux valgus. HDL Cholesterol. Heel spur. Helicobacter pylori Breath Test. Helicobacter pylori Serology. Hemochromatosis Genotype. Hemoglobin Electrophoresis. Hepatitis B. Hepatitis C IgG.

Herniated disc. Hiatal hernia. HLA B Hot zone. Howell-Jolly Body. HS Troponin T. Hyaline Casts. I Icterus. IGF 1. Iliotibial Band Friction Syndrome. Immunity and herd immunity. Inhibin B. Insomnia acute or chronic. Ionized Calcium. Iron profile. Irritable bowel syndrome.

K Karyotype. Ketones routine urine test. Kidney Cells. Kidney Disease nephropathy. L Lactiferous ducts. Lateral epicondylitis.

LDL Cholesterol. Leflunomide Metabolite. Leukocytes esterase. Leukocytes routine urine test. Liver profile. Lumbar Facet Syndrome. Lumbar osteoarthritis. Lumbar sprain. Lying Aldosterone. Lying Renin. Lyme Disease. Lymphogranuloma venereum. M Macadamia Nuts. Maintenance of Wakefulness Test. Mean Corpuscular Hemoglobin. Mean Corpuscular Volume. Mean Platelet Volume. Medial epicondylitis. Meniscal lesion. Microbiological stool analysis by PCR. Mixed Casts.

Molluscum contagiosum. Mono Test. Multiple Sleep Latency Test. Mumps IgG and IgM. N N respirator mask. Nocturnal Paediatric Oximetry. Nucleated Red Blood Cells. O Oats. Obstructive sleep apnea. OI Cell Cold Agglutinin.